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SUBJECT: Roc's reading notes for June, 2015

1) Catechins in berries and grapes have major health benefits -(consider joining our Teaberry Trial (Science 29 May 15) Catechins, also found in blackberries and grapes, are antioxidants linked to improved cardiovascular health, reduced prostate cancer risk, and lower blood cholesterol. Caffeine and other methylxanthines are central nervous stimulants.

2)Response to reader's question: Olive oil helps with weight loss - Dear Dr. Ordman, I am a big fan of your nutritional reports, and I thank you so much for providing them. I've read online about one study by you saying it's possible to lose a pound a week by eating a tablespoon of olive oil.
Here's where I read about it:
http://www.medhelp.org/posts/Healthy-Cooking/Daily-Tablespoon-of-Olive-Oil/show/2498124 But when I search online, I can't find the study. Is there an online link you can share that shows the study itself?
 ROC REPLY: Thanks for the kind words.   The link states “Recent research from Beloit College in Wisconsin, reported that taking 1 tablespoon per day, can help those trying to lose weight, by shedding a pound per week. “ Unfortunately, my pilot study has been frequently misrepresented. There are actually three ingredients in my weight loss cocktail tested in my double blind clinical trial: olive oil, leucine, and DHA. Here is the publication:  http://chemistry.beloit.edu/Ordman/postppt/167weightloss.pdf
Here is my online rather lengthy explanation of my weight loss research:
http://chemistry.beloit.edu/Ordman/nutrition/indices/iweightloss.htm
And this link on that page shows how to try this:
Products and dosages for nutrient signaling for weight control
Good luck, 
Roc

3) Ways to rejuvenate (vs. ways to extend healthspan) Laughter, thinking about sex, music, esp singing with other people, exercise, proper diet and supplements (see my website and newsletter), thinking, esp. learning new physical and mental activities, change of environment, healthful friends that encourage you, sensory stimulation, optimism/positive thinking/good psychoneuroimmunology

4) Transplanting healthy stem cells may prevent pathology and extend lifespan - (Science 5 June 15 ) The findings provide insights into the molecular events driving WS pathology, reveal similarities between Werner and Hutchinson-Gilford progeria syndromes (HGPS), and hint at the potential reversibility of the aging process, at least at the cellular level.  Transplantation of healthy MSCs into a WS mouse model improved mean life span and bone density. Restoration of heterochromatin suppressed the senescent phenotype, indicating that repair of DNA damage may not be required to reverse the cellular phenotypes. More importantly, they raise the possibility that reversal of age-associated MSC dysfunction may be a valid mechanism to slow aging and prevent associated diseases. A major outstanding question is whether the restoration of heterochromatin organization seen in tissue culture cells would translate into a means to rescue the regenerative ability of the aged—thereby preventing pathology and extending life span.

5) Maintain your muscles for a healthy brain - Individuals with sarcopenia are not only more likely to have single but also to have dual impairment in cognitive and physical function. Interventions designed to prevent sarcopenia and improve muscle strength may help reduce the burden of cognitive and physical impairments of functionality in community-dwelling seniors. Clinical Interventions in Aging March 2015

6) 200 mg daily of vitamin C is inadequate for healthy blood levels in many people, fewer colds with 400mg a day - May 11, 2015  LINUS Pauling Institute webinar on vitamin C 1-2pm - LPI vitamin C webinar, Alex Michels- He notes that older people, smoker and diabetics need higher levels of vitamin C, so 200 mg is inadequate for healthy blood levels. Blood level goes up as you supplement over 20 days to maximum  about 60 mircomolar; his slide recommends 400 mg/day; gets up to 100 micromolar. High dose vitamin C meta=analysis shows people get fewer colds. IV vitamin C has shown cancer benefit with pancreatic cancer and lymphomas, not sure about every type of cancer.

7) Early exposure of children to routine infections protects against the most common childhood cancer - (Science 22 May 15) Scientists have long noticed that children who went to day care early in life are less likely to develop the most common childhood cancer: acute lymphoblastic leukemia (ALL). Now, a study that unravels the molecular mechanism driving ALL may explain why early exposure to routine infections might boost the immune system and ultimately help protect against the disease.

8) Rejuvenating protein doubted -  (Science 22 May 15) It was a mind-boggling observation. Hook up the circulatory systems of a young mouse and an old one, and the elderly animal seems to be rejuvenated. In several high-profile papers, two last year in Science, a Harvard University team reported that the protein declines in older animals, and that replacing it rebuilds muscles, the brain, and the heart. But work described this week by a team at the Novartis Institutes for BioMedical Research in Cambridge, Massachusetts, challenges GDF11's rejuvenating powers.  But Harvard stem cell biologist Amy Wagers, who led much of the original work, says the Novartis data on GDF11 levels are not persuasive. “We remain convinced that at least one form of GDF11 declines in blood with age and that maintaining GDF11 levels in an appropriate physiological range is essential for muscle health,” she says.

9) Active aging involves a general lifestyle strategy that allows preservation of both physical and mental health during the aging process. “I am Active” is a program for this - designed to promote active aging by increased physical activity, healthy nutritional habits, and cognitive functioning. At the conclusion of the program, the experimental group showed significant improvement compared with the control group in the following domains: physical activity (falls risk, balance, flexibility, self-efficacy), nutrition (self-efficacy and nutritional status), cognitive performance (processing speed and self-efficacy), and quality of life (general, health and functionality, social and economic status).

- Roc, Nutrition Investigator
*To be added or removed from the nutrition research Email List . *To review the disclaimer*To ask Roc a question. http://chemistry.beloit.edu/Ordman/I feel sorry for people who don't drink. When they wake up in the morning, that's as good as they're going to feel all day.-Frank Sinatra

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