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SUBJECT: J Nutrition Apr, 2015

In just 6 months, a healthier diet can change DNA methylation to reduce cancer risk - Lower levels of global DNA methylation in tissue and blood have been associated with increased cancer risk. Conversely, cross-sectional analyses of healthier lifestyle patterns have been associated with higher levels of global DNA methylation. Over a 12-mo period, changes in percentage body fat and plasma glucose concentrations were positively associated with LINE-1 DNA methylation and LUMA DNA methylation levels, respectively. Similarly, 12-mo changes in dietary measures such as vegetable, protein, and total caloric intake were positively associated with changes in LUMA DNA methylation, as was intake of fruit positively associated with changes in LINE-1 DNA methylation. Conclusions: Our hypothesis-generating results suggest that lifestyle modifications may be associated with changes in global DNA methylation detectable at 6 and 12 mo.

Vegetables decrease about 30%, meat increases about 30% risk of dying from a stroke - The data suggest that glutamic acid and glycine intakes may be associated with risk of stroke mortality. The teaberry study Dr. Rolf Martin and I are conducting is related to this article, which shows how intake of certain amino acids are likely to promote life and death.

Dark fruits and veggies have antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities - Anthocyanins are versatile and plentiful flavonoid pigments found in fruit and vegetables with dark color, including purple cabbage, purple grapes, blueberries, cherries, raspberries, and black rice. Accumulating evidence has shown that anthocyanins display a wide range of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities. These findings demonstrate that anthocyanin supplementation exerts beneficial metabolic effects in subjects with type 2 diabetes by improving dyslipidemia, enhancing antioxidant capacity, and preventing insulin resistance. 

Vitamin D reduces risk of getting diabetes - Subjects with PreDM and low circulating 25(OH)D concentrations are the subgroup of nondiabetic individuals who are the most insulin resistant and have impaired β-cell function, attributes that put them at enhanced risk of T2DM. Vitamin D deficiency in children was associated with low household income, high TV viewing, and little playing outside.

A pro-inflammatory diet (sugar and saturated fats vs. omega-3s, fiber and antioxidant vitamins) increases chronic kidney disease - A proinflammatory diet was associated with systemic inflammation as well as with reduced kidney function in a combined analysis of 2 community-based cohorts of elderly individuals. Diet may play a central role in the regulation of chronic inflammation and possibly also in kidney health. Nutrients that are considered anti-inflammatory, such as n–3 PUFAs, fiber, or vitamins, were associated with better kidney function, lower risk of albuminuria, and slower kidney function decline. Conversely, nutrients assumed to have proinflammatory effects, such as SFAs or sugar, were linked to worsening kidney function.

A poor breakfast promotes diabetes - Plasma glucose, insulin, and ghrelin responses were least favorable when patients with type 2 diabetes consumed a breakfast with a high GI and low fiber.

Flaxseed is very beneficial, extra benefit if you are on statins - Dietary flaxseed lowers cholesterol in healthy subjects with mild biomarkers of cardiovascular disease (CVD). Milled flaxseed lowers total and LDL cholesterol in patients with PAD and has additional LDL-cholesterol–lowering capabilities when used in conjunction with statins. Flaxseed may also lower blood pressure

Omega 3s from safflower oil and fish oil reduce inflammation in your fat- Obesity is associated with chronic low-grade visceral adipose tissue inflammation driven by changes in circulating endotoxin and infiltrating immune cell populations. A 3% menhaden fish-oil + 7% safflower oil diet (wt:wt) exerted an anti-inflammatory and antichemotactic effect on the cross-talk between CD8+ T cells and adipocytes and has implications in mitigating macrophage-centered AT-driven components of the obese phenotype.

- Roc, Nutrition Investigator
*To be added or removed from the nutrition research Email List . *To review the disclaimer*To ask Roc a question. http://chemistry.beloit.edu/Ordman/
"I seem to stagger around this agonized world like a clown, dressed in happiness, hoping to reach the hearts and minds of the young." -Pete Seeger

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