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SUBJECT: J Nutrition Mar, 2015

Many articles on the pathogenic effects of sugars and artificial sweeteners to people and offspring -Sugar-sweetened products promote poor health - These results suggest that SSP consumption is associated with less favorable values for insulin sensitivity, HDL cholesterol, and serum vitamin D in men and women at risk of type 2 diabetes mellitus vs. baseline values and values during dairy product consumption. Pathogenic effects of sugars and artificial sweeteners -  It was proposed that the effects of liquid calories consumed as beverages may differ from those consumed as food. Energy intake in the form of sugar-sweetened beverages is, indeed, incompletely compensated for by reduction of solid calorie intake. High fructose corn syrup (HFCS) may be more deleterious than sucrose. A continuously growing body of evidence points to a potential role of gut microbiota on host intermediary metabolism. Dietary sugars, and even artificial sweeteners, are known to substantially influence the composition of gut microbiota and may thus indirectly alter the host’s metabolism. Compared to table sugar, HFCS reduces survival and fitness of offspring - High-fructose corn syrup consists of fructose and glucose monosaccharides, which are in the dissacharide sucrose, or table sugar. Female mice initially fed the F/G diet experienced a mortality rate 1.9 times the rate and produced 26.4% fewer offspring than females initially fed sucrose.

Celery and parsnips also reduce risk of cancer - Heterocyclic aromatic amines (HAAs) are a group of carcinogenic compounds that are produced during heating of protein-containing foods. Exposure of humans to HAAs is mainly through consumption of overcooked meats and fish. Several epidemiologic studies have shown a positive association between HAA intake and colorectal and mammary cancer risk. PhIP, the main danger in grilled meat, itself is not genotoxic but requires activation in order to become carcinogenic. Specifically, compounds present in apiaceous vegetables (e.g., celery and parsnips) inhibit CYP1As, whereas cruciferous vegetables (e.g., broccoli and cabbage) and the bioactive compounds they contain induce both activating (CYP1As) and detoxifying (GSTs and UGTs) enzymes. 

Food insecurity is associated with poor sleep in 50 million Americans - Food insecurity is one of the most serious nutrition-related health issues in the United States today. The magnitude of the problem is enormous. In 2013, for example, almost 50 million Americans lived in food-insecure households. The extent of food insecurity remains very high and, despite the end of the Great Recession, rates have not returned to the food insecurity levels of 2007. Food insecurity is associated with depression - Household Food Insecurity Is Positively Associated with Depression among Low-Income Supplemental Nutrition Assistance Program Participants and Income-Eligible Nonparticipants.

Many articles on the benefits of a higher quality diet - Higher diet quality (top quintile) was significantly and consistently associated with an 11–28% reduced risk of death due to all causes, CVD, and cancer - compared with the lowest quintile. Healthy diet reduces the risk of heart disease and low-grade inflammation - A healthy diet rich in fish, fruit, and vegetables, but moderate in alcohol and low in dairy products and meat, has been associated with a lower rate of incident cardiovascular disease (CVD). These data suggest that the dietary modification of endothelial dysfunction and low-grade inflammation, processes that are important in atherothrombosis, is possible. A DASH type diet reduced mortality 25%, a Western diet increased it 37% in healthy women over 16 yrs - A DASH-style diet high in intake of whole grains and low in consumption of red meat is associated with reduced mortality rates in healthy African-American women.

EPA(fish oil) lessens effects of a high-fat diet -  EPA ameliorates a 45% high fat-diet effects at least in part by increasing oxygen consumption and fatty acid oxidation and reducing adipocyte size, adipogenesis, and adipose tissue inflammation, independent of obesity.

Green algae (in the spirulina supplement I take daily) prevents obesity - We evaluated the antiobesity effects. Siphonaxanthin found in green algae potently inhibited adipocyte differentiation and significantly suppressed lipid accumulation.

Low vitamin D levels are associated with depression -  Results suggest that lower concentrations of circulating vitamin D are associated with increased likelihood of having depressive symptoms among apparently healthy workers. Depressive symptoms were inversely associated with 25(OH)D. 

Multivitamin/mineral use for over 3 yrs is associated with less heart disease in US women - Multivitamin-mineral (MVM) products are the most commonly used supplements in the United States, followed by multivitamin (MV) products. We observed no significant association between CVD mortality and users of MVMs or MVs compared with nonusers; however, when users were classified by the reported length of time products were used, a significant association was found with MVM use of >3 y compared with nonusers. we found an association between MVM use of >3 y and reduced CVD mortality risk for women when models controlled for age, race, education, body mass index, alcohol, aspirin use, serum lipids, blood pressure, and blood glucose/glycated hemoglobin. Our results are consistent with the 1 available RCT in men.

With age, people like salt more and sweets less

Black tea and coffee inversely associated with mortality - Higher coffee and black tea intake was inversely associated with mortality in never-smokers, light to moderate alcohol intake was inversely associated with mortality regardless of smoking status, heavy alcohol intake was positively associated with mortality in ever-smokers, and there was no association between sugar-sweetened beverages and green tea and mortality.

High protein diets are associated with good (HDL) cholesterol and lower BMI and waist size - Protein intake above the RDA attenuates cardiometabolic risk in overweight and obese adults during weight loss. Americans of all body weights typically consume protein in excess of the RDA. Higher-protein diets are associated with lower BMI and waist circumference and higher HDL cholesterol compared to protein intakes at RDA levels. Our data suggest that Americans who consume dietary protein between 1.0 and 1.5 g/kg BW.


- Roc, Nutrition Investigator
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