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1. Harvard University (Walter Willett) School Obesity Prevention Recommendations Healthy schools, healthy weight Inside and outside the classroom, there are many ways to promote healthy eating. One of the main avenues that schools can use to positively affect health is also one most directly in line with every school’s mission: educating students. Nutrition and physical activity lessons can be woven into the curriculum--in core classroom subjects, physical education, and after-school programs--to teach skills that help students choose and maintain healthy lifestyles. In addition to teaching evidence-based nutrition and activity messages, school physical education should focus on getting students engaged in high-quality and regular activity.
2. Cause and likely cure for hangovers - - From Juvenon newsletter - Why does excessive alcohol consumption make your head hurt? the liver is scanning and filtering the foods for pathogens, viruses, bacteria and toxins. 80 percent to 90 percent of the germ-fighting cells, known as macrophages, are located in this organ. The liver is also responsible for acting on toxic chemicals in our environment. when you drink too much alcohol, the production of toxic metabolites of ethanol makes life miserable, leading to a terrible morning-after headache and more. Chronic alcohol consumption can have serious deleterious effects on our bodies including, but not limited to, the liver, heart and central nervous system. the first metabolite of ethanol, acetaldehyde, was a potent oxidant, and toxic to cells, it was probably the primary causative agent for ethanol’s side effects. acetate may be the primary hangover-producing ethanol metabolite, in levels as much as 100 to 1000 times higher.  Taurine Detoxifies Ethanol. taurine is functioning as a nutrient in the removal of the headache-producing, tissue toxic acetate.
3. Proper building design could aid microbiome - Microscopic organisms permeate our bodies and our buildings. While some of these microbes are detrimental to our health, others keep us alive. Jessica Green believes that we're designing buildings to keep microbes out -- regardless of whether they're good or bad -- and calls for a new breed of "interior groundskeepers.”
4. Avoid creatine supplements– speaker at Beloit, creatine involved in muscle growth, but supplements not recommended
5. Berries are great for your brain - ANN NEUROL 2012;72:135–143 - berries are particularly high in a subclass of flavonoids called anthocyanidins, which can cross the blood–brain barrier and localize in areas of learning and memory (eg, hippocampus).  Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.
6. DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex. Jennifer L. J. Heaney, Douglas Carroll & Anna C. Phillips, AGE, Vol. 35 (2) (March, 2013)
23 minutes of treadmill exercise increases DHEA levels and decreases cortisol levels, both beneficial for health and longevity.  This study was done in people 60-77 years old.
7. Chronic training increases blood oxidative damage but promotes health in elderly men, David de Gonzalo-Calvo, Benjamín Fernández-García, Beatriz de Luxán-Delgado, Susana Rodríguez-González, Marina García-Macia, Francisco Manuel Suárez, Juan José Solano, María Josefa Rodríguez-Colunga & Ana Coto-Montes Age 01/2012
Long-term trained elderly men to analyse the effects of chronic training on an aged population. We collected blood samples from two groups of male volunteers older than 65 years who maintain a measure of functional independence: These results indicate that chronic exercise from middle age to old age increases oxidative damage; however, chronic exercise appears to be an effective strategy to attenuate the age-related decline in the elderly.
8. Skip your nap? - Cognitive deficit is associated with phase advance of sleep–wake rhythm, daily napping, and prolonged sleep duration—a cross-sectional study in 2,947 community-dwelling older adults, Tung Wai Auyeung, Jenny Shun Wah Lee, Jason Leung, Timothy Kwok, Ping Chung Leung, Jean Woo & Yun Kwok Wing AGE 2012
The participants who had lower MMSE mini-mental examination score went to bed earlier and woke up earlier, The MMSE score decreased when the sleep duration prolonged from 7 h to ?10 h . Whether this is a manifestation of early pre-clinical dementia and whether its recognition with early stabilization can slow cognitive decline remain elusive.
9. Weight Loss Strategies for Adolescents, David S. Ludwig, MD, PhD, JAMA. 2012;307(5):498-508.
Childhood obesity may lead to adult obesity because of greater duration of ex- cessive weight gain; the tendency for obesity-promoting diet and physical activity habits to track into adulthood8; persistence of biological changes that promote obe- sity involving, for example, fat cell size, number, or distribution9; and psychosocial issues that cause weight gain and/or antagonize weight loss, including poverty and depression. Adult obesity, in turn, may cause childhood obesity through in utero metabolic programming as discussed in the text; parental modeling of obesity- promoting diet and physical activity habits11; normalized perception of excess weight, wherein obesity in a child may be unrecognized or encouraged12; and parental psy- chosocial issues. Medical and economic costs for society will likely escalate unless this cycle can be arrested.
10. Reversing T cell immunosenescence: why, who, and how, Pierre Olivier Lang et al, AGE June 2013, Volume 35, Issue 3,  pp 609-620
Considerations are given to recent advances made in the field of age-specific immune interventions that could contribute to maintain immune protection, to improve quality of life, and/or to promote healthy aging of the growing part of the population.
11. Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8) , Sara Cuesta et al, pp 659-671, AGE - Melatonin administration was able to improve pancreatic function in old SAMP8 mice and to reduce HOMA-IR improving their insulin physiology and glucose metabolism.
12. The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad , Alex J. Wadley et al, pp 705-718 , AGE. We review evidence suggesting that exercise may ameliorate the age-related decline in vascular function, through reductions in both oxidative stress and inflammation.
13. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells , Jian Zhang, et al, pp 807-820 , AGE
Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation. These results suggest that (1) a significant prevention of OVX-induced bone cell senescence from adult rats can occur after only 14 days consumption of a BB-containing diet immediately prior to puberty, and (2) the molecular mechanisms underlying this effect involves, at least in part, prevention of collagen degradation.
14. Zinc: dietary intake and impact of supplementation on immune function in elderly
Eugenio Mocchegiani, et al, pp 839-860 , AGE. Nutrient “zinc” is a relevant micronutrient involved in maintaining a good integrity of many body homeostatic mechanisms, including immune efficiency, owing to its requirement for the biological activity of many enzymes, proteins and for cellular proliferation and genomic stability. Old people aged 60–65 years and older have zinc intakes below 50% of the recommended daily allowance on a given day. 
15. Limitations to exercise in female centenarians: evidence that muscular efficiency tempers the impact of failing lungs , Massimo Venturelli et al, pg 861-870 , AGE
Centenarians are an outstanding model of successful aging, with genetics and healthy lifestyle certainly being key factors responsible for their longevity. Exercise capacity has been identified to play an important role in healthy aging, but a comprehensive assessment of the limitations to maximal exercise in this population is lacking. Metabolic cost of a given absolute work rate was consistently lower, ∼46% less than the young at maximal effort. Centenarians have significant limitations to gas exchange across the lungs during exercise,
16. Neuromuscular adaptations to concurrent training in the elderly: effects of intrasession exercise sequence, Eduardo Lusa Cadore et al, pp 891-903, AGE
Performing strength prior to endurance exercise during concurrent training resulted in greater lower-body strength gains as well as greater changes in the neuromuscular economy (rectus femoris) in elderly.
17. Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study, Alexis Elbaz et al, pp 943-952, AGE Slow walking speed is associated with increased mortality in the elderly, but it is unknown whether a similar association is present in late midlife. Walking speed measured in late midlife seems to be an important marker of mortality risk; multiple factors, in particular inflammatory markers, partially explain this association.
18. Relative improvements in endurance performance with age: evidence from 25 years of Hawaii Ironman racing Romuald Lepers et al, pg 953-962, AGE The aim of the study was to analyse the changes in participation and performance trends of older (>40 years of age) triathletes between 1986 and 2010 at the Hawaii Ironman triathlon.  Linear regression showed that males older than 44 years and females older than 40 years significantly improved their performances in the three disciplines and in the total time taken to complete the race.
19. Fitness, fatness and survival in elderly populations Jean Woo, Ruby Yu & Forrest Yau, pg 973-840, AGE
This study examines the relative importance of fitness versus fatness in predicting mortality in elderly populations aged 70 years and over, and whether fitness may account for the ‘paradoxical’ relationship between better survival and increasing weight. The findings underscore the importance of maintaining physical fitness through exercise and re-confirm the importance of weight maintenance in reducing mortality risk.

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You can’t evolve all of the computational systems for social intelligence until you have that tendency that you want to be close to others. –pg. 68 Scientific Am. Mind Nov/Dec 2012  
Roc Ordman for appointments or phoning pls email 24hrs ahead
Professor, Biochemistry, Beloit College, fall schedule
Classes 10-12MWF; 1-3TR; 9-12T
http://chemistry.beloit.edu/Ordman/

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