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J Nutrition June, 2006
Bone, Body Weight, and Weight Reduction: What Are the Concerns?
Regulation of Protein Synthesis by Leucine Starvation Involves Distinct Mechanisms in Mouse C2C12 Myoblasts and Myotubes
[cancer protection] Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells J. Nutr. 2006 136: 1477-1482 Neoangiogenesis is required for tumor development and progression. Many solid tumors induce vascular proliferation by production of angiogenic factors, ... Overall, the glycosylated flavonoids (i.e., naringin, a constituent of citrus fruits, and rutin, a constituent of cranberries) induced the greatest response to treatment at the lowest concentration in MDA human breast cancer cells. Inhibition of VEGF release by flavonoids, tocopherols, and lovastatin in these models of neoplastic cells suggests a novel mechanism for mammary cancer prevention.
[fishoil good during pregnancy] Maternal Fish Oil Supplementation during Lactation Does Not Affect Blood Pressure, Pulse Wave Velocity, or Heart Rate Variability in 2.5-y-old Children J. Nutr. 2006 136: 1539-1544 Maternal (n-3) PUFA deficiency is associated with higher blood pressure (BP) later in life in rat offspring, and early intake of (n-3) PUFA in formula-fed infants was shown to modify later BP. BP, heart rate (HR), and heart rate variability (HRV) are affected by dietary (n-3) PUFA in adults...In conclusion, maternal FO supplementation had no overall effect on BP, PWV, or HRV of the children, indicating that (n-3) PUFA intake of Danish mothers may be sufficient in this sense. However, children's dietary intake of (n-3) PUFA might have a beneficial effect on BP in childhood.
[internal cocoa good for skin]Long-Term Ingestion of High Flavanol Cocoa Provides Photoprotection against UV-Induced Erythema and Improves Skin Condition in Women J. Nutr. 2006 136: 1565-1569 Dietary antioxidants contribute to endogenous photoprotection and are important for the maintenance of skin health. In the present study, 2 groups of women consumed either a high flavanol (326 mg/d) or low flavanol (27 mg/d) cocoa powder dissolved in 100 mL water for 12 wk...Evaluation of the skin surface showed a significant decrease of skin roughness and scaling in the high flavanol cocoa group compared with those at wk 12. Dietary flavanols from cocoa contribute to endogenous photoprotection, improve dermal blood circulation, and affect cosmetically relevant skin surface and hydration variables.
[fishoil good during pregnancy] Maternal Dietary (n-3) Fatty Acid Deficiency Alters Neurogenesis in the Embryonic Rat Brain
[Vitamin C and E good for nervous system] A Combined Deficiency of Vitamins E and C Causes Severe Central Nervous System Damage in Guinea Pigs
[All about amino acids] The Amino Acid Assessment Workshop Series - Part of Development of Year 2000 Dietary Guidelines
Introduction to the 1st Amino Acid Assessment Workshop - The 1st AAAW was held in Tokyo in June, 2001. The purpose of this AAAW was: i) to review the roles and metabolism of dietary amino acids in relation to cell and organ function and ii) to identify the possible consequences associated with abnormal or unusual, in particular, high, intakes in human subjects. The focus of the discussions was intended to be, as far as possible, on mechanisms and quantification. It was planned that a working framework for assessment of the consequences of abnormal amino acid intakes might be developed, together with a number of the details of a research program required to generate a sufficient knowledge base for purposes of making sound and effective recommendations and policies.
Introduction to the 2nd Amino Acid Assessment Workshop Metabolism and Function of Amino Acids J. Nutr. 133:2015S-2020S, June 2003 - The 2nd AAAW was held in Hawaii in October, 2002, and the major focus of this workshop was on how recent advances in biology made somewhat before and during this genome-sequencing era (and the associated technology) might help to better understand the mechanisms involved and improve the ability to predict the responses of individuals to altered intakes of amino acids and their safety. Some of the issues of interest in anticipation in this workshop were: i) to determine how to define and identify molecular signatures of a pathological response to amino acid intake; ii) to see if we can identify a distinct set of genes that differentiate adequacy from excess for specific amino acids; iii) to explore the power of a microarray approach to establish a molecular profile of amino acid adequacy/excess; and iv) to decide on which organs/tissues to focus a major effort with respect to assessing the pathophysiological consequences and mechanisms of excessive intakes. Should it be the brain, the liver and/or the gut, for example, and how might the effects in such organs be probed in a noninvasive way?
Introduction to the 3rd Amino Acid Assessment Workshop Required Intakes of Amino Acids J. Nutr. 2004 134: 1555S-1557S - The first two AAAWs, as noted above, focused attention largely on metabolism of amino acids, their mechanism(s) of action, and the function of amino acids. For this workshop we focus more attention on intakes to meet physiological needs, the host and dietary factors that affect these needs and the nature of the host response, variation in responses to and levels of intake of amino acids among individuals in populations. All of this is to be viewed with an eye as to how the upper level of the safe range may be determined/set. It is recognized that this will require an approach that differs from that established for nonnutrients, which is based on hazard identification, hazard characterization, exposure assessment, and risk characterization (14–18), involving a dose-response assessment to define levels of intake without appreciable adverse effects. However, it is clear from the recent initiative by the U.S. Food and Nutrition Board/Institute of Medicine (FNB/IOM), which was to set new dietary reference intakes including tolerable upper levels (ULs) (19), that application of the approach used for nonnutrients would be unworkable for nutrients, including amino acids.
Introduction to the 4th Amino Acid Assessment Workshop Branched chain amino acids J. Nutr. 2005 135: 1576S-1579S
Introduction to the 5th Amino Acid Assessment Workshop Sulfur-containing amino acids J. Nutr. 2006 136: 1633-1635.