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specific nutrition by age and gender

 

 
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SAMe [S-adenosylmethionine]



Claim

Link

Citation

SAMe provides major improvement from major depression. [more]

SHOULD WE DO CLAIMS LIKE THIS OR LOWER ONES?

Sufficient hepatic SAMe reduces the risk of cirrhosis in the liver.

Am. J Clin. Nutr. November 2002. vol. 76 no. 5 11775-11825

SAMe helps produce and break down brain chemicals such as dopamine, serotonin, and melatonin.

“S-adenosylmethionime.” University of Maryland Medical Center. N.p., 24 June 2013.

Recommended doses of SAMe, varying based on ailment:

  • Depression: 800-1,600mg per day, in two divided doses (morning and afternoon)

  • Fibromyalgia: 400mg twice a day for 6 weeks

  • Osteoarthritis: 600-1,200mg per day in 2-3 divided doses

  • Alcoholic liver disease: 600-1,200mg per day by mouth in divided doses for 6 months to enhance liver function


“S-adenosylmethionime.” University of Maryland Medical Center. N.p., 24 June 2013.

There are some studies suggesting that SAMe is effective in inhibiting cancer tumor cells.

 

“S-adenosylmethionime.” University of Maryland Medical Center. N.p., 24 June 2013.

SAMe often cannot be synthesized by people with liver disease. A study involving 123 alcoholic liver cirrhosis sufferers showed that a two-year SAMe treatment improved rates of survival and delayed need for liver transplants more effectively than a placebo.

 

“S-adenosylmethionime.” University of Maryland Medical Center. N.p., 24 June 2013.

In a number of short-term studies, SAMe supplements were found to be as effective as nonsteroidal anti-inflammatory drugs in adults with hip, knee, or spine osteoarthritis.

 

“S-adenosylmethionime.” University of Maryland Medical Center. N.p., 24 June 2013.

The antidepressive efficacy of 400mg/d SAMe given intramuscularly and 1600mg/d SAMe given orally is significantly better tolerated than, and comparable to, a 150mg/d oral dose of imipramine (prescription antidepressant).

 

Am. J. Clin. Nutr. November 2002. vol. 76 no. 5 11725-11765

Clinical studies have shown that, at doses of 200-1,600mg/d, SAMe is better than a placebo and as effective as tricyclic antidepressants in alleviating depression.

 

Am. J. Clin. Nutr. November 2002. vol. 76 no. 5 11585-11615

S-adenosyl methionine treatment has the potential to be a new therapeutic method for atherosclerosis.

 

Molecules and Cells. October 2013. vol. 36. 376-384

Augmenting existing medication with SAMe in patients with stage II treatment-resistant depressive disorder (TRD) may be well-tolerated and effective.

 

The Scientific World Journal 2013. 2013. Article ID 204649, 5 pages

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