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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

December headlines from Roc, Nutrition Investigator

by Roc (click here for full post)

Wishing you a joyful and grateful December. Here are headlines to inspire New Year’s hope.

Four ingredients in Mito-C are in 5 recent articles: Sulforaphane delays aging harm and neurodegeneration; Vitamin K promotes healthy blood sugar, reduces risk for type II diabetes, reduces inflammation, reduces abdominal fat; Oxidative stress accelerates decline in cognition, (can be delayed by vitamin C twice a day); Taking niacin confers heart protection; Exercise aids executive function and prefrontal oxygenation; Exercise lowers rate of inflammation and thus of death from heart disease; Supercentenarians have unique immune cells enabling them to live beyond 110 years-live vegetarian, active, drug/alcohol/smoke free.”  Average life expectancy in US is now 78.8 yrs; “Leading geneticist says reversing the aging process in humans could be 20 years away”; There has been an exponential growth of experiments to extend lifespan,”Protein levels in people’s blood, a mere nine proteins were enough, can predict their age”; aging isn’t a smoothly continuous process.”; Recent studies support melatonin as an anti-ageing compound whose multifaceted functions may lessen the processes of ageing;  Late life metformin treatment limits cell survival and shortens lifespan; Hormone replacement therapy lowers risk of dying 31% during menopause- Previous study indicating rise in breast cancer risk was flawed; 31,000 older Americans suffered fatal injuries from falls.  Both Mito-C and Triumph have ingredients which help reduce the risk of falling; more breast cancer in women who eat the most red meat.  People live longest with a peasant diet – no meat, eat greens, grains, nuts, beans, tubers; Nutrients with ULs: calcium, choline, copper, fluoride, iodine, iron, manganese, molybdenum, nickel, phosphorus, selenium, vitamin B6, vitamin C, vitamin D, and zinc

Reader’s question: i’m taking mito-c faithfully but am confused.  you and i have talked about needing 500 mg of c twice daily to interrupt the possibility of cancer reproducing.  mito-c has less than 500 of c.  i do take it 2x/day so that’s 500 but not 1000.  please un-confuse me. ROC EXPLAINS: 500mg twice a day of vitamin C saturates the blood, but it not the dose to kill cancer cells.  It is not necessary to take vitamin C supplements if you are taking Mito-C. 250mg twice a day is nearly as effective at saturating blood, and sufficient for most people. With vitamin K to amplify the vitamin C free radicals, it may aid against cancer. If you take another vitamin C containing supplement, like AREDs, then you have plenty. 

LONG NOTES

Sulforaphane – role in aging and neurodegeneration–[Mito-C ingredient]- SFN preserves proteome homeostasis (proteostasis) by activating the proteasome, which has been shown to lead to increased cellular lifespan and prevent neurodegeneration. ; Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease
Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815645/

Vitamin K –[Mito-C ingredient]- promotes healthy blood sugar metabolism, reduces risk for type II diabetes (Diabetes Care 33:1699), reduces inflammation by INACTIVATING NF-kB (Food Func 9:450), reduces abdominal fat (Eurp J Clin Nutr 72:136)

Accelerated decline in cognition in a mouse model of increased oxidative stress– Oxidative stress reduced by vitamin C –[Mito-C ingredient]

Taking niacin daily confers heart protection: –[Mito-C ingredient]- In conclusion, addition of niacin to existing medical regimens for patients with coronary artery disease and already well-controlled LDL levels favorably improves the distribution of lipoprotein particle sizes and inflammatory markers in a manner that would be expected to confer atheroprotection. 

The effects of cardiorespiratory fitness on executive function and prefrontal oxygenation in older adults

Why regular exercise lowers rate of death from heart disease – it reduces inflammation by reducing blood stem cells production of leptin – Science 29 Nov pg 1091

From PNAS thanks to Ann: Supercentenarians have unique immune cells enabling them to live beyond 110 years.  For the rest of us, try to live like a 7th Day Adventist, vegetarian, active, drug/alcohol/smoke free.”  Average life expectancy in US is now 78.8 yrs.

“Leading geneticist says reversing the aging process in humans could be 20 years away” (60 Minutes report broadcast Sunday, December 8)

https://med.stanford.edu/news/all-news/2019/12/stanford-scientists-reliably-predict-peoples-age-by-measuring-pr.html
“Protein levels in people’s blood, a mere nine proteins were enough, can predict their age, a Stanford study has found. The study also found that aging isn’t a smoothly continuous process.”

This review depicts four categories of melatonin’s protective effects on ageing-induced molecular and structural alterations.Ageing brings about deterioration of circadian rhythmicity and thereby also deregulates melatonin synthesis. Recent studies support melatonin as an anti-ageing compound whose multifaceted functions may lessen the processes of ageing

Late life metformin treatment limits cell survival and shortens lifespan. Metformin exacerbates aging-associated mitochondrial dysfunction causing fatal ATP exhaustion.

Nutrients with ULs: calcium, choline, copper, fluoride, iodine, iron, manganese, molybdenum, nickel, phosphorus, selenium, vitamin B6, vitamin C, vitamin D, and zinc

Exponential growth of experiments to extend lifespan.

Hormone replacement therapy is beneficial during menopause. Previous study indicating rise in breast cancer risk was flawed, HRT lowers risk of dying 31% vs those who do not use it, Economist  Dec 14 pg 14

31,000 older Americans suffered fatal injuries from falls.  Both Mito-C and Triumph have ingredients which help reduce the risk of falling. Falls cost the US $50 billion in 2015. 18% increased risk of heart disease from red meat once a day; 23% more breast cancer in women who eat the most red meat.  People live longest with a peasant diet – no meat, eat greens, grains, nuts, beans, tubers. – AARP December

– Roc, Nutrition Investigator

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Roc Ordman, Prof Emeritus of Biochem, Beloit College

Supplement designer-https://triumphhealthcorp.com

Newsletter: http://www.nutritioninvestigator.org/Ordman/

“What is the most just thing? To sacrifice!” Pythagoras

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