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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

Nutrition Investigator Roc notes for June

by Roc (click here for full post)

Lots of short summaries from my readings I think should be shared:

From John Furber 2018 Harvard/Paul F. Glenn Symposium on Aging:

In humans, aging increases chronic inflammation that predisposes to age related diseases. Dietary restriction (DR) decreases chronic inflammation; A lower epigenetic age results from eating fish, fruits, vegetables, moderate alcohol, higher education, higher income, and more exercise; Rapamycin slows epigenetic aging in keratinocytes, but this may not apply to other cells; biomarkers of ageing based on DNA methylation have enabled accurate age estimates for any tissue across the entire life course. These multi-tissue ‘epigenetic clocks’ link developmental and maintenance processes to biological ageing. We have settled on 353 CpG locations for our test of epigenetic age or DNA methylation age.

AGE meeting 2018 “Improving Resiliency to Delay Aging ” Unofficial Meeting Notes by John D. Furber – Muscle satellite cells regenerate injured muscles. In old age, they do not do much regeneration. They are restored by any of the following: Caloric Restriction to 60% of Ad Libitum; Antioxidant supplements to diet; Rapamycin; or senolytic drug treatments; We put old mice on a periodic fasting-mimicking diet (FMD). This restores white blood cell counts to young levels; Epigenetic clocks do not yet do as well for lifespan prediction as blood pressure and smoking status; Dietary Methionine restriction (MR) inhibits cancer development in rats and mice. We compared MR with Total Sulfur Amino Acid Restriction (SAAR). SAAR produces better reductions of cholesterol and insulin than does MR. We found no adverse effects from either MR or SAAR diets; Moderate alcohol in mice extends lifespan; Eating yogurt of the strain L.Reuteri 6475 stimulates the hypothalamus to stimulate other cells to make oxytocin-recall L. Reuteri beneficial to people with autism [note Kefir Roc drinks contains L. Reuteri];  Dudley Lamming says Rapamycin has bad side effects ; Metabolites measured in blood are able to predict future mortality. Higher PUFA is very good. Higher Glucose is bad; In the longest human longitudinal study, over past 70 years, the best predictors of lifespan have been Grip strength and gait speed.

 https://www.nutraingredients.com/Article/2016/06/13/Supplement-halts-and-reverses-cognitive-decline-Mouse-study Note the use of the word “augment” in the quote below.  This is age reversal – rejuvenation. “A multi-ingredient food supplement has shown anti-ageing properties that may reduce brain cell loss.  The team said the blend of vitamins C, D, folic acid (B9), green tea extract, omega-3 and its synergistic effects could help slow the progress of conditions like Alzheimer’s and Parkinson’s, and even augment cognitive performance. The brain is vulnerable to free radical damage. This is due to its high content of unsaturated fatty acids, high oxygen metabolism (20% of total body consumption) and relatively low levels of endogenous antioxidants. Not only did the supplementation improve cognitive function in older mice, but brain cell density and brain mass were maintained at levels comparable to young mice. Previous research has concentrated on antioxidants, anti-inflammatories or a few ingredients at a time, enabling the identification of potential benefits in isolation. The downside however, prevents the study of interactive effects, which may emerge in more complex formulations. “

Great reading from a kind reader: Happily ever after: 25 ways to live well into old age

Niacin supplementation may have risks. An article from GRG indicates that supplementing with niacin may stimulate senscenscent cells to promote cancer.

“Medicine nearly always works better when the patient is in a positive frame of mind. “ Research has proven the positive psychological effects of hugging, even 10 minutes with a teddy bear. 

A method proven to help children manage hyperactive behavior and improve inhibitory control is for them to take a semester in a choral or instrumental group. Science 364: 647

Effects of dietary supplements on depressive symptoms in older patients: a randomized double-blind placebo- controlled trial.  Experimental group was given full daily value of calories, and were significantly less depressed.

Dietary pattern and depressive symptoms in middle age. Conclusion: In middle-aged participants, a “processed food” dietary pattern is a risk factor for depression five years later, while a “whole food” pattern is protective.

From Bruce Ames: An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the poor, young, obese, and elderly, at little cost. (1) DNA damage. Deficiency of vitamins B-12, folic acid, B-6, C or E, or iron or zinc appears to mimic radiation in damaging DNA by causing single- and double-strand breaks, oxidative lesions or both. Half of the population may be deficient in at least one of these micronutrients. (2) The Km concept. Approximately 50 different human genetic diseases that are due to a poorer binding affinity (Km) of the mutant enzyme for its coenzyme can be remedied by feeding high-dose B vita- mins, which raise levels of the corresponding coenzyme. Many polymorphisms also result in a lowered affinity of enzyme for coenzyme. (3) Mitochondrial oxidative decay. This decay, which is a major contributor to aging, can be ameliorated by feeding old rats the normal mitochondrial metabolites acetyl carnitine and lipoic acid at high levels.

These initial findings support further larger trials to determine chromium’s efficacy 1000mcg (chromium/day) in maintaining normal glucose regulation, reducing binge eating and related psychopathology, promoting modest weight loss, and reducing symptoms of depression in individuals with binge eating disorder

We live in a transformational moment for understanding the etiology of mental disorders. The previous leap in understanding occurred 60 years ago, which led us to incorporate psychopharmacology into our curricula to address the chemical basis of neurotransmitter function, especially as explained through the then-popular catecholamine hypothesis.
The current revolution is broader, consisting of the rapidly accumulating knowledge of how inflammation, microbiome imbalance (gut dysbiosis), oxidative stress, and impaired mitochondrial output affect brain function. Suitable interventions for fighting inflammation, restoring normal gut function, reducing oxidative stress, and improving mitochondrial metabolism incorporate lifestyle variables, including nutrients and probiotics. This article invites readers to stay abreast of this emerging model of the biological basis of mental illness, given that it has particular relevance for those readers interested in alleviating the suffering of individuals with mental disorders.

Evidence-based data suggest that light therapy, St John’s wort, Rhodiola rosea, omega-3 fatty acids, yoga, acupuncture, mindfulness therapies, exercise, sleep deprivation, and S-adenosylmethionine are effective in the treatment of mood dis- orders. Clinical trials of vitamin B complex, vitamin D, and methylfolate found that, while these were useful in physical illness, results were equivocal in patients with mood disor- ders.

Although the determinants of mental health are complex, the emerging and compelling evidence for nutrition as a crucial factor in the high prevalence and incidence of mental disorders suggests that diet is as important to psychiatry as it is to cardiology, endocrinology, and gastroenterology. Primarily positive results were found for replicated studies testing S-adenosylmethionine (SAMe), methylfolate, omega-3 (primarily EPA or ethyl-EPA), and vitamin D.

We argue for the critical role of oxidative damage in causing the mitochondrial dysfunc- tion of aging. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age.  Acetyl-L-carnitine, a high-energy mito- chondrial substrate, appears to reverse many age-associated deficits in cellular function.

 After age and other potential confounders were adjusted for, multivitamin use was associated with longer telomeres. Compared with nonusers, the relative telomere length of leukocyte DNA was on average 5.1% longer among daily multivitamin users.

Have a wonderful June! -Roc *To be added or removed from the nutrition research Email List . *To review the disclaimer*To ask Roc a question. http://www.nutritioninvestigator.org/Ordman/ What is the most just thing? To sacrifice – Pythagoras

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