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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

Nutrition Investigator Roc reading to live for further Mother’s Days

by Roc (click here for full post)

In the process of developing 2 nutritional supplements and moving to a new city, I have fallen behind on reading. Here is an update on Advances in Nutrition. Headlines are followed by longer summaries.

HEADLINES:

Mar 2019 Advances in Nutr

At least half your diet should be fruits and veggies.

Omega-3 [(n-3)] fatty acids have been linked to healthy aging throughout life. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer’s disease.

DNA methylation is an epigenetic modification critical to normal genome regulation and development. The vitamin folate is a key source of the one carbon group used to methylate DNA.

All artificial sweeteners are controversial because of health risks.

Jan, 2019 Advances in Nutr

Increased intake of refined carbohydrates and refined vegetable oils rich in omega-6 fatty acids contributes to depression occurring in 1 in 15 adults.

Diets high in protein coupled with exercise preserve muscle mass.

EPA and DHA (fish oil) can reverse troubles in your microbiome.

DHA and curcumin may act directly or indirectly (indeed via the gut) to suppress inflammatory, thrombotic, and/or vasoconstrictor mechanisms associated with impaired endothelial function, reducing brain damage as we age.

The global obesity epidemic continues its relentless advance, currently affecting >2 billion people.

Probiotics are living microorganisms that confer health benefits to the host when administered in adequate amounts. 

November, 2018 Advances in Nutr

Today, it seems that nutrition is in a state of great confusion, especially for the general public. We hypothesize that such a state of confusion is mainly the result of the reductionist paradigm applied to nutrition research for more than a century.

Adherence to a diet with high antioxidant properties may reduce the risk of all-cause mortality.

Eating a breakfast with protein, calories, and solid food helps in weight management.

Phytoestrogens may have a positive influence on glycemia and could be used for diabetes prevention in women.

Some dietary supplements could beneficially modulate sperm quality parameters and affect male fertility. 

DETAILS:

Top vaccine expert gets flu vaccine in October and again in January. The vaccine provides 40% protection initially, reducing to only 20% after 3 months. 19 Apr Science pg 224

Coffee intake was associated with reduced non-melanoma skin cancer 

 risk in a dose-dependent manner. Compared with those who drank coffee less than weekly, the risk was significantly reduced in daily drinkers and with increasing number of cups per day, 50% for 3 cups a day. Black tea also reduced risk (NIH).

Tel Aviv University researchers have discovered why Parkinson’s patients have difficulty transitioning from walking through turning around to sitting. It has led to new advice for patients that when turning to sit down, they should first turn, briefly stop, and then sit down.
https://www.timesofisrael.com/turn-stop-then-sit-a-research-based-guide-for-parkinsons-patients/

The first 3D printed heart. Researchers at Tel Aviv University have unveiled the world’s first 3D-printed heart using human tissue that contains cells, blood vessels, ventricles and chambers. Although there are still many challenges ahead, fully working 3D printed hearts will one day be available for transplant into patients.


From John Furber 2018 Harvard/Paul F. Glenn Symposium on Aging:

In humans, aging increases chronic inflammation that predisposes to age related diseases. Dietary restriction (DR) decreases chronic inflammation; In a recent breakthrough, biomarkers of ageing based on DNA methylation have enabled accurate age estimates for any tissue across the entire life course. These multi-tissue ‘epigenetic clocks’ link developmental and maintenance processes to biological ageing. We have settled on 353 CpG locations for our test of epigenetic age or DNA methylation age. Rapamycin slows epigenetic aging in keratinocytes, but this may not apply to other cells. Personally, I am not taking any Rapamycin (yet); A lower epigenetic age results from eating fish, fruits, vegetables, moderate alcohol, higher education, higher income, and more exercise, based upon cross sectional study.

Readers question: I’m learning about micronutrient therapy.  I have heard that research goes back 27 years. Also, I’m trying a micronutrient product that uses “micronization” – to get more absorbed into the cells and brain barrier.

Benefits reported by test subjects include the ability to reduce anxiety from stress, less depression, better and more restful sleep, a greater sense of well-being, and more energy! The product is called “B.You. ROC RESPONSE: Though I have read nothing about this product or the benefits it claims, the ingredients seem to be legitimate substances. My impression is that any supplement that claims noticeable benefits quickly is suspicious, unless it has caffeine.  While there is great biochemical evidence of the benefit of many supplement ingredients, like vitamins and SAMe, many intelligent people do not take any, without rapid visible harm.

READER COMMENT: Please share my article on sleep guidance for children with autism spectrum disorder: https://www.sleepreports.com/autism-and-sleep-problems-advice/. It’s super in-depth and I think it would make an awesome addition to your page.

READERS QUESTION: I am approaching menopause. Should I use hormone replacement therapy to maintain my estrogen levels?

I’m sorry it’s taken me so long to respond. To be honest, I haven’t practiced medicine in sixteen years. I retired from clinical practice the day my youngest was born (April 2, 2003). I have, however, maintained my board certification in Obstetrics and Gynecology (for whatever that’s worth). Basically that means that read around 45 articles annually to try and stay abreast of the literature.
     Every now and then the American Board of OB/GYN throws up a new obstacle for me to maintain my board certification. This year, they decided to require a provider identification number. So before I could access any of the literature, I had to first figure out if I had this number, and if not, figure out how to get one. Well, I just learned that I do in fact have one, and was able to plug it in and get to the literature.
      Now to your question. It used to be simple to answer that question. As long as you did not have any factors that put you at risk for harmful side effects, I would have unequivocally recommended hormone therapy (HT). Not too long after I stopped practicing, however, the answer became much more difficult, with evidence suggesting that not only were the protective heart effects not present, but the harms were much greater than we would have ever anticipated.
     So, the last “Practice Bulletin” from the American College of OB/GYN (ACOG) addressing this issue was published in January of 2014, and reaffirmed in 2018. Your gynecologist is really the best person to answer this question for you, because they should understand not only your past medical history, but also your current health status, bot h of which play an important role in helping you decide the best course for you. They should also understand your reasons for contemplating HT. Do you want to treat vasomotor symptoms, i.e. hot flashes, night sweats? Are you more concerned with vaginal dryness and/or pain with intercourse? While systemic (either oral or patch) HT is the most effective treatment for vasomotor symptoms due to menopause, there are many reasons why it might not be the right choice for you. 

HINT: There are NO posts in the category called Test