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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

ANTIONC

by Roc (click here for full post)

BELOW ARE QUOTATIONS FROM PEER-REVIEWED SCIENTIFIC LITERATURE RELATED TO THE INGREDIENTS AND DOSAGES PRESENT IN THE NUTRITIONAL SUPPLEMENT “ANTIONC”.

“For most of mankind’s existence, scientists wallowed in lethal ignorance regarding the critical need for humans to supplement with enough vitamin D. We fear the same knowledge deficit exists today regarding vitamin K.” The Remarkable Anticancer Properties of Vitamin K – LIFE EXTENSION MAGAZINE 2010

Despite more than 2.4 million papers published on cancer research to date, conventional medicine has largely failed to identify safe, low-cost, effective methods of cancer intervention and prevention. Mizuta T, Ozaki I. Clinical application of vitamin K for hepatocellular carcinoma. Clin Calcium. 2007 Nov;17(11):1693-9.

VITAMIN C QUOTATIONS FROM PEER-REVIEWED LITERATURE

Vitamin C above 2 g twice a day was not absorbed. But that intake produced a bladder [AA] above 1 mM in all participants. Conclusion: Taking 2 g of AA BID will increase [AA] in the bladder to a level likely to kill cancer cells that cause SBC. Taking that dosage 2 consecutive days a week is likely to reduce the recurrence rate of SBC substantially. Two Grams BID Is an Oral Dosage of Vitamin C to Reduce the Risk of Recurrence of Superficial Bladder Carcinoma

[https://www.scirp.org/Journal/PaperInformation.aspx?PaperID=53879#.VNn5mLDF-Hw]

More fears about vitamin C proven wrong!  Some research 3 years ago suggested a mechanism by which vitamin C might cause harm. New research in PNAS shows that mechanism actually can prevent genetic damage by removing peroxidized lipids, and “may explain in part how the vitamin helps prevent diseases like cancer and heart disease.” – C&E News 12/20/04

VITAMIN K QUOTATIONS FROM PEER-REVIEWED LITERATURE

Vitamin K helps make four of the 13 proteins needed for blood clotting. Its role in maintaining the clotting cascade is so important that people who take anticoagulants such as warfarin (Coumadin) must be careful to keep their vitamin K intake stable.  Lately, researchers have demonstrated that vitamin K is also involved in building bone. Low levels of circulating vitamin K have been linked with low bone density, and supplementation with vitamin K shows improvements in biochemical measures of bone health. (1) A report from the Nurses’ Health Study suggests that women who get at least 110 micrograms of vitamin K a day are 30 percent less likely to break a hip than women who get less than that. [see references at https://www.hsph.harvard.edu/nutritionsource/vitamin-k/

Vitamin K help cardiac rhythm. Vitamin K activates the protein osteocalcin, which strengthens bone mass, but decalcifies soft tissues like arterial walls reducing blood pressure. (link: vitamin D and vitamin Kblood pressure; source: LPI meeting 2009; added 6/2009)

A recent study found that patients with early-stage Alzheimer’s disease consumed less vitamin K than did cognitively intact control subjects. (J Am Diet Assoc. 2008 Dec;108(12):2095-9). (Link: vitamin Kand Alzheimers; Source: Alzheimers newsletter:
http://www.healthandage.com/html/min/iananda/newsletter.htm; added 6/2009)

Like dietary lipids and other fat-soluble vitamins, ingested vitamin K is incorporated into mixed micelles via the action of bile and pancreatic enzymes, and it is absorbed by enterocytes of the small intestine [10]. … Compared to the other fat-soluble vitamins, very small amounts of vitamin K circulate in the blood.

https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/

Can Too Much Vitamin k2 be harmful?Kidney disease: Too much vitamin K can be harmful if you are receiving dialysis treatments due to kidney disease. … In fact, high doses of vitamin K can make clotting problems worse in these people.

2017 Yuan K3.pdf – Measuring K3

“menadione is a physiological human metabolite that could be measured in the urine. Daily excretion of menadione [vitamin K3] was of the order of 5 μg, but this was increased when exogenous doses of phylloquinone [K1, MK-7, or MK-4 [K2] were given by the oral route but not when given by the s.c. route, despite the latter being efficiently released into the plasma compartment.“ Vitamin K Nutrition, Metabolism, and Requirements: Current Concepts and Future Research  Martin J. Shearer Xueyan Fu Sarah L. Booth, https://academic.oup.com/advances/article/3/2/182/4557941

VITAMINS C & K COMBINATION QUOTATIONS FROM PEER-REVIEWED LITERATURE

“The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.” Deficiency of alkaline and acid DNase is a hallmark in all non-necrotic cancer cells in animals and humans. These enzymes are reactivated at early stages of cancer cell death by vitamin C (acid DNase) and vitamin K(3) (alkaline DNase). Moreover, the coadministration of these vitamins (in a ratio of 100:1, for C and K(3), respectively) produced selective cancer cell death.”  Verrax [2003] J, Cadrobbi J, Delvaux M, et al. The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy. Eur J Med Chem. 2003 May;38(5):451-7.

“Purpose: To evaluate the safety and efficacy of oral Apatone® (Vitamin C and Vitamin K3) administration in the treatment of prostate cancer in patients who failed standard therapy.

Conclusion: Apatone showed promise in delaying biochemical progression in this group of end stage prostate cancer patients.” Tareen [2008] B, Summers JL, Jamison JM, et al. A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy. Int J Med Sci. 2008;5(2):62-7.

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