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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

Special Science issue “Diet and Health” from Roc Nutrition Investigator

by Roc (click here for full post)

The 16 Nov Science is a prize, Special Issue “Diet and Health”! I have to share a few bits:

pg 736-Reprogrammed cells could tackle brain damage – in mice they can turn astrocytes into neurons to repair stroke damage, perhaps Parkinsons and Alzheimers

pg 765 Current controversies (NUTRITION Questions we do not know the answers to!): 1. Do diets with various carbohydrate-to-fat proportions affect body composition (ratio of fat to lean tissue) independently of energy intake? Do they affect energy expenditure independently of body weight? 2. [WE DO NOT UNDERSTAND IF KETOGENIC DIETS HELP?] Do ketogenic diets provide metabolic benefits beyond those of moderate carbohydrate restriction? Can they help with prevention or treatment of cardiometabolic disease? 3. What are the optimal amounts of specific fatty acids (saturated, monounsaturated, polyunsaturated) in the context of a very-low-carbohydrate diet? 4. [WE DO NOT UNDERSTAND WHAT CHOLESTEROL LEVEL MEANS] What is the relative importance for cardiovascular disease of the amounts of LDL cholesterol, HDL cholesterol, and triglycerides in the blood, or of lipoprotein particle size, for persons on diets with distinct fat-to-carbohydrate ratios? Are other biomarkers of equivalent or greater importance? 5. What are the effects of dietary fat amount and quality across the lifespan on risk of neurodegenerative, pulmonary, and other diseases that have not been well studied? 6. What are the long-term efficacies of diets with different carbohydrate-to-fat proportions in chronic disease prevention and treatment under optimal intervention conditions (designed to maximize dietary compliance)? 7. What behavioral and environmental interventions can maximize long-term dietary compliance? 8. What individual genetic and phenotypic factors predict long-term beneficial outcomes on diets with various fat-tocarbohydrate compositions? Can this knowledge inform personalized nutrition, with translation to prevention and treatment? 9. How does variation in the carbohydrate-to-fat ratio and in sources of dietary fat affect the affordability and environmental sustainability of diets?

PG 770 – A time to fast? Caloric restriction can improve fitness and health span-Cut food intake 15-40% OR do not eat for a 12 hr period each day OR fast 24-48 hr each week OR cut intake 30% five consecutive days each month.

Pg 776-Gut microbiota – Short chain fatty acids made by healthy microbiome signal central nervous system etcd. For energy homeostasis, suppression of inflammation, etc. reducing weight and chronic disease (so eat whole grains, yogurt, vegetables)

Pg 781 – Swifter, higher, stronger, NUTRITION FOR ATHLETES – sleep low, train low, eat carbs, train high, eat low carb meal, sleep low. Note few products enjoy evidence of efficacy for athletes, but see page 785 for table of brain and muscle fatigue factors and nutrition strategies for gold medal performance. EXTRAORDINARY Figure 2 should be on training wall of every locker room and gymnasium – Bicarbonate to prevent muscle acidosis, when to hydrate, caffeine pre/during event, carbs 24h pre-event, creatine supplementation between sprints.


– Roc, Nutrition Investigator

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Is there anything more exciting in life than seeking answers? Isaac Asimov


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