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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

Long notes Oct, 2018

by Roc (click here for full post)

Treatment for Fibromyalgia

Notes of Reynaud’s Disease

“Vitamin C Twice a Day Enhances Health” 2010 has been viewed 13,356 times.

I have recently discussed with many people that I am tracking my memory, quantitatively over time, as many my age are fearful of memory loss, and having a quantitative record is helpful.  Here is the test I take and record every few months: https://www.psychologistworld.com/memory/test

Use of facebook correlates with declines in mental and physical health and life satisfaction – New Yorker, Sept 17, 2018, pg 34

Drug pair shows promise to treat sleep apnea. Science pg 1174, 9/21/2018 A small clinical trial showed thatoxybutynin and atomozetine may open the upper airway, eliminating the need for the breathing device and mask now needed by those with sleep apnea.

The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.

US approval for migraine treatment.  The US FDA has just given approval for AJOVY – the only anti-CGRP treatment for the prevention of migraine.  About 40% of migraine sufferers may be candidates for this treatment.

Effective Israeli diagnostics for cervical cancer (see here) have been developed by five Israeli bio-techs.

How healthy is the healthspan concept? By Matt Kaeberlein

From LPI newsletter: Nutrition scientists at the Institute’s Micronutrient Information Center recently published three new articles focused on identifying and combating micronutrient inadequacies. The first of these articles reviews the prevalence of micronutrient inadequacies in the US population. The second highlights specific groups who are at increased risk of micronutrient inadequacy or deficiency – for example, pregnant women or adolescents. The third article examines ways that healthy eating and the use of fortified food and dietary supplements can promote micronutrient adequacy.

Alzheimer’s and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI). This pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise.  These pilot data provide preliminary indications to suggest neuro-exergaming can impact cognitive function, perhaps via neurobiological mechanisms, and as such may provide an effective and practical way to promote healthy aging.

This meta-analysis and systematic review indicated that exercise intervention might improve the cognitive function of AD or slow down the decline of cognition.

Irritable bowel syndrome (IBS) is a complex, functional gastrointestinal ­disorder characterized by chronic abdominal pain or discomfort and altered bowel habits. Despite the global prevalence and disease burden of IBS, its underlying pathophysiology remains unclear. Inflammation may play a pathogenic role in IBS. As evidenced by patients who develop postinfectious IBS, infective gastroenteritis could cause systemic inflammation and altered microbiome diversity, which in turn perpetuates a cycle of chronic, low-grade, subclinical inflammation. Apart from mucosal inflammation, neuroinflammation is probably involved in the pathophysiology of IBS via the “gut–brain” axis, resulting in altered neuroendocrine pathways and glucocorticoid receptor genes. This gives rise to an overall proinflammatory phenotype and dysregulated hypothalamic–pituitary–adrenal axis and serotonergic (5-HT) functioning, which could, at least in part, account for the symptoms of IBS.

This discusses normal sleep and sleep apnea in  human memory processing.  A fundamental problem in the field of obstructive sleep apnea (OSA) and memory is that it has historically minimized the basic neurobiology of sleep’s role in memory. An abundance of evidence suggests that sleep plays a critical role specifically in the processing/consolidation phase, but may do so differentially for memories that were encoded using particular brain circuits.

Taking multiple medications at the same time may have hazardous consequences.  Polypharmacy is the condition of taking multiple drugs for a single condition.  Along with certain chronic conditions, depressive symptoms and an inflammatory marker (neutrophil/lymphocyte ratio) were significantly and independently related to higher daily drug consumption.

Reader’s question: I’m wondering if in your vast reading and research you’ve run across anything that would lead one to think taking collagen, as I am, for disc degeneration, would be helpful or useful? So many people our age have this.
I take 4 type 2 at night and 4 type 1 &3 in the morning.
I have searched to find anything authoritative about this. While there are many ads for collagen products, I have been unable to find any research or hospital advice advocating collagen for disc degeneration. Here is the best article I found that explains why it is unlikely to be helpful. Of course, if something is working for you, perhaps it does.  I do note that vitamin C is advocated to help make effective collagen.

Reader Question: If I eliminate high methionine foods, what’s left to eat? That was my concern also, so I asked the expert on this, Rolf Martin. He said the important thing is the ratio of methionine, bad, to amino acids that lower methionine levels, like glycine and serine. So cheese is a good thing to eat, even though it is listed as a high methionine food.

Reader comment: I came across your site  http://www.nutritioninvestigator.org/Nutrition/hlthlnks.htm while researching for helpful Health & Wellness information, so thought I’d reach out. It’s unfortunate, drug deaths in America are on the rise and as of 2016, drug overdoses have become the leading cause of death among Americans under 50. Fortunately, studies have also shown that regular exercise and a healthy diet can decrease the chances of mental illness and substance abuse.

In the spirit of lending a helping hand to your online readers and anyone seeking help, will you be able to assist us by adding our new Wellness Resources section  https://www.therecoveryvillage.com/resources/fitness-and-nutrition/ to your list? We believe exercise and nutrition play a critical role in mental health; something that is especially true when we consider the risks of mental health issues and substance use disorders. With your help, we’ll be able to raise awareness about the benefits fitness and good nutrition have on mental health. Thank you very much for your help!
Carlos Davila, Awareness Advocate, The Recovery Village®


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