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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

1801 Nutrition investigator is back with lengthy notes

by Roc (click here for full post)

Happy New Year! Sorry I have so many notes to catch up on. I finally submitted my NIH proposal Jan 3, hoping to prevent people from getting cancer with an inexpensive tablet. Cross your fingers – only 1 in 20 chance of funding around July. Below are brief headlines with longer notes here.

FOR EVERYONE

The Economist – Inflammation is a major cause of cancer and heart disease. Reduce inflammation with fish/oil, exercise, no fours diet!

 

Ingested capsaicinoids (capasaicin) can prevent low fat high carbohydrate diet and high fat diet induced obesity by regulating the NADPH oxidase and Nrf2 pathways

 

“LDL isn’t really as bad as they make it out to be – at least not until it becomes oxidized.” Roc comment: That is why I tell people it is important to take 500 mg vitamin C twice a day, as that prevents LDL oxidation!

 

Reduced caloric intake and more protein increase healthspan in multiple studies. Overall, the results from multiple studies show that both reduced calories intake (CR) and the ratio between macronutrients, namely the protein to carbohydrates ratio, positively impact lifespan.

 

New Yorker 9/11 – Metastasis of cancer depends not only on the cancer, but also the person who has it.  Inflammation is one of the main triggers of metastasis, so reducing inflammation can reduce heart disease, cancer, and metastasis of cancer.

 

Use of Dietary Supplements among older adults continues to be high in the United States, with 29%of users regularly taking $4 DSs, and there is a high concurrent usage of them with prescription medications.

 

For diabetics, a no-needle glucose meter is expected this year.

 

READER NOTE: People with a sensitive stomach may have alternatives to taking aspirin to prevent heart disease – sent by a qualified reader.

 

Preventing plagiarism in college (follow this link).

 

FOR WEIGHT CONCERNS

 

Cancer Is promoted through obesity-induced inflammation. Science 358: 1130 – Obesity  is a growing global epidemic and rivals smoking as the leading preventable risk factor for cancer incidence and  mortality, being responsible for an estimated 20% of cancer-related deaths in adults. Obesity underlies a number of distinct but interconnected health conditions that have profound consequence for physiology including hyper-nutrition, dysbiosis, hypercholesterolemia, metabolic syndrome, and chronic inflammation. Inflammation, in particular, is known to be a potent driver of cancer initiation and progression.

 

This study suggests older adults who are trying to slim down should consider lifting weights. The diets that cause muscle loss are usually low calorie, low-protein diets. Deficiencies in protein and calories cause the body to break muscle down. This provides amino acids the body needs to maintain organ function. So if you’re on a low-calorie diet to lose weight, make sure you’re eating enough protein. But there’s more you can do.

 

Injection that melts fat is in clinical trials.  Israeli startup Raziel Therapeutics has developed an injectable molecule that apparently melts away fat cells. The new synthetic small molecule was discovered by Professor Shmuel Ben-Sasson of Hebrew University almost by accident. Raziel is conducting phase 2a clinical testing on 32 US patients.

 

IF YOU ARE OLDER
Exercise 1 hr/day doubles brain function if 80 year olds. Daily calf muscle pump stimulation (passive exercise) for 1 hour/day, or less, was found to be sufficient to normalize DBP and significantly improve performance on the executive function tests  almost twice that of the control group. REVERSAL of cognitive impairment in a hypotensive elderly population using a passive exercise intervention

 

Dietary interventions have been shown to influence ­various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration. COGNITIVE and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia. There are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients.

 

The predominant sleep position in adults is on the side. This preference increases with age and BMI. SLEEP positions and nocturnal body movements based on free living accelerometer recordings association with demographics lifestyle and insomnia symptoms.
For people over 50, smiling improves effectiveness of flu vaccination, as does 400iu of vitamin E for 3 days before and after the shot. AARP –  For 2016, the vaccine worked for people 50-64, but was ineffective for those over 65, unless they were feeling happy when they got vaccinated.  It may be that stress hormones suppress the immune system, or that mood is linked to sleep, diet, and exercise.

 

READER NOTE: Rethinking cholesterol – more evidence to avoid statins.

“LDL isn’t really as bad as they make it out to be – at least not until it becomes oxidized.” Roc comment: That is why I tell people it is important to take 500 mg vitamin C twice a day, as that prevents LDL oxidation! It is oxidized LDL that becomes sticky and causes plaque. Instead of statins, consider just exercise, wise eating, and vitamin C.  Get an LDL/HDL ratio less than 3.5 to 1 (2 to 1 is great), and that is what matters – relatively high HDL and lots of antioxidants in the diet. Statins have not been shown to benefit anyone but those who have had a heart attack already – and are likely to harm people who haven’t had a heart attack.

 

Perhaps you should have your doctor check your apoB level instead of cholesterol to avoid heart attacks? Science 358:1237-8 Is it time to retire cholesterol tests?  It is cheaper to measure apoB, which may be a better measure of risk for heart disease.  LDL cholesterol may not be good enough. It misses many who get heart attacks, and indicates many who have no problems.

 

You can work toward brain health by following recommendations of the Alzheimer’s Assoc or Am. Heart Assoc, or by reading how to rejuvenate your brain.

Coming soon – Curing glaucoma in the blink of an eye. Israel’s Belkin Laser has developed an innovative laser ray system that can treat glaucoma in just one second every year, instead of daily eye drops. There is no need for direct contact of the equipment with the eye. Belkin recently raised $5 million of funding.

https://www.youtube.com/embed/5HkXjWPSpxU?rel=0  http://www.belkin-laser.com/

 

Treatment for Parkinson’s major new drug – Propanolol used to lower blood pressure also increases the risk of Parkinson’s disease (PD) by 220%.  Salbutamol used for asthma lowers the risk of PD by 34%, and should be considered to treat anyone with PD symptoms.  Science 1 Sept pg 869

 

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