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The Nutrition InvestigatorThe health and nutrition blog by Dr. Roc Ordman.

First major trial of cheap medicine to extend our healthspan

by Roc (click here for full post)

And the J Nutrition Sept, 2015 from Roc Nutrition Investigator

Please read the longer summaries after these headlines
FIRST TRIAL TO SLOW AGING - Metformin could add more than 2 yrs to healthspan, saving $7.1 Trillion in the US over 50 years. SOY VS DAIRY Recent evidence suggests that the ingestion of the plant-based proteins in soy and wheat results in a lower muscle protein synthetic response when compared with several animal-based proteins such as wheyPotential antioxidant capacity, in the postprandial period after dairy but not soy meals may represent a further important difference in the response to these sources of fat.  MATURE
Adherence to a healthy diet in midlife that provides micronutrients, fiber, and antioxidants while regulating energy intake increases odds of healthy aging by 50%. OVERWEIGHT Fermentable soluble fibers extracted from legumes (α-galacto-oligosaccharides – α-GOSs), reduce appetite, food intake, and inflammation in overweight subjectsIodine prophylaxis may reduce cardiovascular disease risk in overweight adults. WOMEN Amino Acid Intakes Are Inversely Associated with Arterial Stiffness and Central Blood Pressure in Women. MOTHER AND CHILD Maternal DHA (fish oil) intake is thought to affect development in the offspring. Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children aged 7–12 y.  In this population of children, early high folic acid intakes (beans, lentils, spinach) were associated with a lower body weight and BMI at the age of 6 y. In contrast, early higher methionine (eggs and fish) intakes were associated with unfavorable body composition at the age of 6 y. 

FIRST TRIAL TO SLOW AGING
In Science 18 Sept pg 1275 it states, “On a blazingly hot morning this past June, a half-dozen scientists convened in a hotel conference room in suburban Maryland for the dress rehearsal of what they saw as a landmark event in the history of aging research. In a few hours, the group would meet with officials at the U.S. Food and Drug Administration, to pitch an unprecedented clinical trial—nothing less than the first test of a drug to specifically target the process of human aging.” They will use metformin, an anti-diabetes drug. They predict it will extend healthspan by more than 2 yrs, saving $7 Trillon over the next 50 yrs in the US.

SOY VS DAIRY
Recent evidence suggests that the ingestion of the plant-based proteins in soy and wheat results in a lower muscle protein synthetic response when compared with several animal-based proteins such as whey. Most plant proteins have a relatively low leucine content. Various strategies may be applied to augment the anabolic properties of plant proteins. These may include the following: 1) fortification of plant-based protein sources with the amino acids methionine, lysine, and/or leucine; 2) selective breeding of plant sources to improve amino acid profiles; 3) consumption of greater amounts of plant-based protein sources; or 4) ingesting multiple protein sources to provide a more balanced amino acid profile.

Postprandial lipemia represents a risk factor for chronic diseases, including type 2 diabetes. The increased concentrations of plasmalogens, with potential antioxidant capacity, in the postprandial period after dairy but not soy meals may represent a further important difference in the response to these sources of fat.

MATURE
Our study demonstrated the association between empirically derived overall dietary patterns in midlife and healthy aging  after 13 y of follow-up.   Adherence to a healthy diet in midlife that provides micronutrients, fiber, and antioxidants while regulating energy intake increases odds of healthy aging by 50%.

OVERWEIGHT
Dietary fibers have been associated with a reduction in appetite and energy intake. Fermentable soluble fibers extracted from legumes (α-galacto-oligosaccharides – α-GOSs), reduce appetite, food intake, and inflammation in overweight subjects. Consumption of α-GOSs for 14 d dose-dependently reduced appetite, food intake, and inflammation in overweight adults.

Our aim was to determine if 200 μg oral iodine daily decreases serum thyrotropin (TSH)
and improves the lipid profile. Our findings suggest that moderate to severe iodine deficiency in overweight women elevates serum TSH and produces a more atherogenic lipid profile and that iodine supplementation in this group reduces the prevalence of hypercholesterolemia. Thus, iodine prophylaxis may reduce cardiovascular disease risk in overweight adults.

WOMEN
Amino Acid Intakes Are Inversely Associated with Arterial Stiffness and Central Blood Pressure in Women. These data provide evidence to suggest that intakes of several AAs intakes of (arginine, cysteine, glutamic acid, glycine, histidine, leucine, and tyrosine) were calculated and are associated with cardiovascular benefits beyond blood pressure reduction in healthy women.

MOTHER AND CHILD
Maternal dietary docosahexaenoic acid (DHA) intake is thought to affect development in the offspring. Maternal DHA beneficially affected offspring social behavior after weaning and mildly attenuated sickness behavior after an inflammatory challenge in pigs.

Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children aged 7–12 y.  Our results show that a higher self-reported intake of PUFAs and a higher ratio of PUFAs to SFAs are positively associated with LM and negatively associated with visceral adiposity and %BF,

Deficiency of vitamin B-6, vitamin B-12, folate, folic acid, or methionine may lead to dysregulation of DNA methylation, which might lead to disturbed energy and lipid metabolism.  In this population of children, early high folic acid intakes (beans, lentils, spinach) were associated with a lower body weight and BMI at the age of 6 y. In contrast, early higher methionine (eggs and fish) intakes were associated with unfavorable body composition at the age of 6 y. 

- Roc, Nutrition Investigator
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The message of Voltaire and Pangloss is, “in the face of a Heaven known to be decidedly unbenevolent, it takes unrelenting, thankless, and almost ill-rewarded work to cultivate happiness here on earth”…-New Yorker 9/21/15 pg 104

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